The hand as a sign-post to ocular disease--I.

.:X ......... hydroxyproline content. Arachnodactyly is diagnosed when the metacarpal index (length/ width of metacarpals II-V) is greater than 8 4. It is also found in association with homo: :. ....cystinuria, and in some patients with homozygous (SS) sickle-cell disease. The main ocular defect, which occurs in almost every case, is ectopia lentis, though microphakia and spherophakia, miosis due to hypoplasia of the iris, and mesodermal FIG. 1.-Arachnodactyly. dysgenesis, are also found. Abnormalities of the cornea, sclera (blue sclerotics), and retina have also been reported.